abstract：BACKGROUND:Insufficient specificity of the high-risk human papillomavirus (hrHPV) assay in primary cervical cancer screening results in unnecessary referral. Additional assays to triage hrHPV-positive women are needed to improve molecular cervical cancer screening. DNA methylation is a promising biomarker in cervical c...

journal_title：Clinical epigenetics

authors： Pun PB,Liao YP,Su PH,Wang HC,Chen YC,Hsu YW,Huang RL,Chang CC,Lai HC

更新日期：2015-08-21 00:00:00

abstract：:Interleukin 1 and its receptors are associated with allergic diseases such as asthma. In the present study, we measured DNA methylation at the IL1R1 and IL1R2 gene loci and assessed for associations with asthma-related phenotypes and gene expressions. We found that asthmatic and atopic individuals have higher IL1R2 pr...

journal_title：Clinical epigenetics

authors： Gagné-Ouellet V,Guay SP,Boucher-Lafleur AM,Bouchard L,Laprise C

更新日期：2015-08-05 00:00:00

abstract：BACKGROUND:Aging is a complex phenomenon and characterized by a progressive decline in physiology and function of adult tissues. However, it hasn't been well established of the correlation between aging and global DNA methylation and hydroxymethylation that regulate the growth and development of higher organisms. RESU...

journal_title：Clinical epigenetics

authors： Xiong J,Jiang HP,Peng CY,Deng QY,Lan MD,Zeng H,Zheng F,Feng YQ,Yuan BF

更新日期：2015-07-23 00:00:00

abstract：BACKGROUND:Recent developments in genomic sequencing have advanced our understanding of the mutations underlying human malignancy. Melanoma is a prototype of an aggressive, genetically heterogeneous cancer notorious for its biologic plasticity and predilection towards developing resistance to targeted therapies. Eviden...

journal_title：Clinical epigenetics

authors： Lee JJ,Sholl LM,Lindeman NI,Granter SR,Laga AC,Shivdasani P,Chin G,Luke JJ,Ott PA,Hodi FS,Mihm MC Jr,Lin JY,Werchniak AE,Haynes HA,Bailey N,Liu R,Murphy GF,Lian CG

更新日期：2015-06-09 00:00:00

abstract：BACKGROUND:The birth weight of Black neonates in the United States is consistently smaller than that of their White counterparts. Epigenetic differences between the races may be involved in such disparities. The goal of these analyses was to model the role of IGF1 methylation in mediating the association between race a...

journal_title：Clinical epigenetics

authors： Straughen JK,Sipahi L,Uddin M,Misra DP,Misra VK

更新日期：2015-04-21 00:00:00

abstract：BACKGROUND:Prostate cancer (PCa), a highly incident and heterogeneous malignancy, mostly affects men from developed countries. Increased knowledge of the biological mechanisms underlying PCa onset and progression are critical for improved clinical management. MicroRNAs (miRNAs) deregulation is common in human cancers, ...

journal_title：Clinical epigenetics

authors： Costa-Pinheiro P,Ramalho-Carvalho J,Vieira FQ,Torres-Ferreira J,Oliveira J,Gonçalves CS,Costa BM,Henrique R,Jerónimo C

更新日期：2015-04-10 00:00:00

abstract：BACKGROUND:The current epidemic of obesity and associated diseases calls for swift actions to better understand the mechanisms by which genetics and environmental factors affect metabolic health in humans. Monozygotic (MZ) twin pairs showing discordance for obesity suggest that epigenetic influences represent one such ...

journal_title：Clinical epigenetics

authors： Ollikainen M,Ismail K,Gervin K,Kyllönen A,Hakkarainen A,Lundbom J,Järvinen EA,Harris JR,Lundbom N,Rissanen A,Lyle R,Pietiläinen KH,Kaprio J

更新日期：2015-04-02 00:00:00

abstract：BACKGROUND:Epigenetic changes in DNA methylation could regulate the expression of several allergy-related genes. We investigated whether tolerance acquisition in children with immunoglobulin E (IgE)-mediated cow's milk allergy (CMA) is characterized by a specific DNA methylation profile of Th2 (IL-4, IL-5) and Th1 (IL-...

journal_title：Clinical epigenetics

authors： Berni Canani R,Paparo L,Nocerino R,Cosenza L,Pezzella V,Di Costanzo M,Capasso M,Del Monaco V,D'Argenio V,Greco L,Salvatore F

更新日期：2015-03-31 00:00:00

abstract：BACKGROUND:Both forms of facioscapulohumeral muscular dystrophy (FSHD) are associated with aberrant epigenetic regulation of the chromosome 4q35 D4Z4 macrosatellite. Chromatin changes due to large deletions of heterochromatin (FSHD1) or mutations in chromatin regulatory proteins (FSHD2) lead to relaxation of epigenetic...

journal_title：Clinical epigenetics

authors： Jones TI,King OD,Himeda CL,Homma S,Chen JC,Beermann ML,Yan C,Emerson CP Jr,Miller JB,Wagner KR,Jones PL

更新日期：2015-03-29 00:00:00

abstract：BACKGROUND:Type 2 diabetes mellitus (T2D) is highly prevalent in Middle-Eastern and North African Arab populations, but the molecular basis for this susceptibility is unknown. Altered DNA methylation levels were reported in insulin-secreting and responding tissues, but whether methylation in accessible tissues such as ...

journal_title：Clinical epigenetics

authors： Toperoff G,Kark JD,Aran D,Nassar H,Ahmad WA,Sinnreich R,Azaiza D,Glaser B,Hellman A

更新日期：2015-03-28 00:00:00

abstract：BACKGROUND:The pathogenesis of systemic lupus erythematosus (SLE) has not yet been completely elucidated. One of the hallmarks of SLE is the production of autoantibodies by uncontrolled over-activated B cells. Early B cell factor 1 (EBF1) contributes to the development, activation, and proliferation of B cells through ...

journal_title：Clinical epigenetics

authors： Luo S,Liu Y,Liang G,Zhao M,Wu H,Liang Y,Qiu X,Tan Y,Dai Y,Yung S,Chan TM,Lu Q

更新日期：2015-03-14 00:00:00

abstract：BACKGROUND:Preeclampsia is one of the leading causes of fetal and maternal morbidity and mortality worldwide. Preterm babies of mothers with early onset preeclampsia (EOPE) are at higher risks for various diseases later on in life, including cardiovascular diseases. We hypothesized that genome-wide epigenetic alteratio...

journal_title：Clinical epigenetics

authors： Ching T,Ha J,Song MA,Tiirikainen M,Molnar J,Berry MJ,Towner D,Garmire LX

更新日期：2015-03-13 00:00:00

abstract：BACKGROUND:Neuroblastoma (NB) is the most common extracranial pediatric solid tumor with a highly variable clinical course, ranging from spontaneous regression to life-threatening disease. Survival rates for high-risk NB patients remain disappointingly low despite multimodal treatment. Thus, there is an urgent clinical...

journal_title：Clinical epigenetics

authors： Yáñez Y,Grau E,Rodríguez-Cortez VC,Hervás D,Vidal E,Noguera R,Hernández M,Segura V,Cañete A,Conesa A,Font de Mora J,Castel V

更新日期：2015-02-27 00:00:00

abstract：BACKGROUND:Modification of DNA by methylation of cytosines at CpG dinucleotides is a widespread phenomenon that leads to changes in gene expression, thereby influencing and regulating many biological processes. Recent technical advances in the genome-wide determination of single-base DNA-methylation enabled epigenome-w...

journal_title：Clinical epigenetics

authors： Zaghlool SB,Al-Shafai M,Al Muftah WA,Kumar P,Falchi M,Suhre K

更新日期：2015-01-22 00:00:00

abstract：BACKGROUND:Splicing is more efficient when coupled with transcription and it has been proposed that nucleosomes enriched in exons are important for splice site recognition. Lynch syndrome is a familial cancer syndrome that can be caused by the autosomal dominant inheritance of splice site mutations in the MutL homolog ...

journal_title：Clinical epigenetics

authors： Sloane MA,Hesson LB,Nunez AC,Thompson BA,Ward RL

更新日期：2014-12-13 00:00:00

abstract：BACKGROUND:The mechanism of action of olanzapine in treating schizophrenia is not clear. This research reports the effects of a therapeutic equivalent treatment of olanzapine on DNA methylation in a rat model in vivo.Genome-wide DNA methylation was assessed using a MeDIP-chip analysis. All methylated DNA immunoprecipit...

journal_title：Clinical epigenetics

authors： Melka MG,Laufer BI,McDonald P,Castellani CA,Rajakumar N,O'Reilly R,Singh SM

更新日期：2014-01-02 00:00:00

abstract：BACKGROUND:Smoking is the largest preventable cause of morbidity and mortality in the United States. In previous work, we demonstrated that altered DNA methylation at the aryl hydrocarbon receptor repressor (AHRR) is correlated with self-reported smoking in 19-year-old African Americans with relatively low levels of sm...

journal_title：Clinical epigenetics

authors： Philibert RA,Beach SR,Lei MK,Brody GH

更新日期：2013-10-11 00:00:00

abstract：BACKGROUND:Epigenetic mechanisms are thought to be critical in mediating the role of the intrauterine environment on lifelong health and disease. Twin-twin transfusion syndrome (TTTS) is a rare condition wherein fetuses share the placenta and develop vascular anastomoses, which allow blood to flow between the fetuses. ...

journal_title：Clinical epigenetics

authors： Marsit CJ,Koestler DC,Watson-Smith D,Boney CM,Padbury JF,Luks F

更新日期：2013-10-03 00:00:00

abstract：INTRODUCTION:DNA methylation of CpG islands within the promoter region of genes is an epigenetic modification with an important role in the development of cancer and it is typically mediated by DNA methyltransferases (DNMTs). In cancer cells, global hypomethylation of the genome as a whole and regional hypermethylation...

journal_title：Clinical epigenetics

authors： Kullmann K,Deryal M,Ong MF,Schmidt W,Mahlknecht U

更新日期：2013-05-02 00:00:00

abstract：BACKGROUND:Preeclampsia, a pregnancy complication of placental origin is associated with altered expression of angiogenic factors and their receptors. Recently, there is considerable interest in understanding the role of adverse intrauterine conditions in placental dysfunction and adverse pregnancy outcomes. Since we h...

journal_title：Clinical epigenetics

authors： Sundrani DP,Reddy US,Joshi AA,Mehendale SS,Chavan-Gautam PM,Hardikar AA,Chandak GR,Joshi SR

更新日期：2013-04-26 00:00:00

abstract：: Friedreich ataxia (FRDA) is a debilitating and frequently fatal neurological disorder that is recessively inherited. It belongs to the group of genetic disorders known as the Repeat Expansion Diseases, in which pathology arises from the deleterious consequences of the inheritance of a tandem repeat array whose repeat...

journal_title：Clinical epigenetics

authors： Kumari D,Usdin K

更新日期：2012-01-30 00:00:00

abstract：: Lower than normal levels of oxygen (hypoxia) is a hallmark of all solid tumours rendering them frequently resistant to both radiotherapy and chemotherapy regimes. Furthermore, tumour hypoxia and activation of the hypoxia inducible factor (HIF) transcriptional pathway is associated with poorer prognosis. Driven by bot...

journal_title：Clinical epigenetics

authors： Thirlwell C,Schulz L,Dibra H,Beck S

更新日期：2011-12-05 00:00:00

abstract：:Lymphocytes from the peripheral blood of patients with prostate cancer-the most frequent (noncutaneous) tumor in men-display epigenetic aberrations (altered modes of allelic replication) characteristic of the malignant phenotype. The present study aims to determine whether replication aberrations add certainty to the ...

journal_title：Clinical epigenetics

authors： Cytron S,Stepnov E,Bounkin I,Mashevich M,Dotan A,Avivi L

更新日期：2011-08-01 00:00:00

abstract：:Cyclin D1 is a cell cycle machine, a sensor of extracellular signals and plays an important role in G1-S phase progression. The human cyclin D1 promoter contains multiple transcription factor binding sites such as AP-1, NF-қB, E2F, Oct-1, and so on. The extracellular signals functions through the signal transduction p...

journal_title：Clinical epigenetics

authors： Guo ZY,Hao XH,Tan FF,Pei X,Shang LM,Jiang XL,Yang F

更新日期：2011-08-01 00:00:00

abstract：:Epigenetic mechanisms are thought to play a major role in the pathogenesis of the major psychoses (schizophrenia and bipolar disorder), and they may be the link between the environment and the genome in the pathogenesis of these disorders. This paper discusses the role of epigenetics in the management of major psychos...

journal_title：Clinical epigenetics

authors： Peedicayil J

更新日期：2011-08-01 00:00:00

abstract：:Researchers have begun to examine epigenetic alterations in the placenta, making key advances in understanding the epigenetic regulatory mechanisms of the placenta that define underlying processes of human development and disease. Examining changes in microRNA (miRNA) expression associated with environmental exposures...

journal_title：Clinical epigenetics

authors： Maccani MA,Marsit CJ

更新日期：2011-08-01 00:00:00